Runs of Homozygosity (RoHs) are popular among geneticists as the footprint of demographic processes, evolutionary forces and inbreeding in shaping our genome, and are known to confer risk of Mendelian and complex diseases.Notwithstanding growing interest in their study, ELDERBERRY there is unmet need for reliable and rapid methods for genomic analy
Lipid synthesis and membrane contact sites: a crossroads for cellular physiology
Membrane contact sites (MCSs) are regions of close apposition between different organelles that contribute to the functional integration of compartmentalized DME ORG VIRGIN COCONUT OIL cellular processes.In recent years, we have gained insight into the molecular architecture of several contact sites, as well as into the regulatory mechanisms that u
First aid guidelines for fragile contexts (conflict, disaster and remote areas): Contextualization & Adaptation
Topic: In situations of remoteness to medical care, disaster or conflict, first aid provision is important but challenging.Education for learners in such contexts needs to be adapted according to resources available.This paper explores the educational approach and adaptations recommended by the 2020 IFRC First Aid, Resuscitation and Education Guide
Three Levels of Disease Modification with SGLT-2 Inhibitors: Holy Grail in Vasculopathy
SGLT2 inhibitors have an insulin-independent mechanism of action leading to Vanilla Bean increasing glycosuria and lowering plasma glucose concentration, which results in cardiovascular and renal benefits shown in various studies.Other benefits include improvements in hyperglycemia, decreased fluid retention, reduced weight gain, lower blood pressu
Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro.
The tuberculous granuloma is an elaborately organized structure and one of the main histological hallmarks of tuberculosis.Macrophages, which are important immunologic effector and antigen-presenting cells, are the main cell type found in the tuberculous granuloma and have high tweezer plasticity.Macrophage polarization during bacterial infection h